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Synthesis of Methadone-Med.

Joni

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Formula and synthesis of crystalline (street) methadone
honey hydrochloride:
Chemical Name: 6-(dimethylamino)-4,4-diphenyl-3-heptanone
Chemical formula: C21H27NO.
Mol. weight: 309.445 g/mol
It is most commonly found as the hydrochloride salt.
Melting point: 232 C (with decomposition)
Solubility in water: 1:12
Solubility in ethanol: 1:7
Solubility in chloroform: 1:3

The synthesis of methadone is a fairly simple process. Only a few chemicals and minimal laboratory equipment are required. Here is one way to get honey in a home laboratory.
So, for starters, add 900 ml of ordinary water to a 3-liter container. Pour 900 grams of sodium hydroxide there and mix. The resulting solution is left to cool at room temperature. Then pour the solution into another container. Now, the resulting solution is added to 1120 grams of 1-dimethylamino-2-chloropropane hydrochloride. Mix well. The resulting base (brown oily substance) is separated from the main mass using a separating funnel.

We wash the base with salt water 1-2 times. Oil should be about 800 gm.
Now we proceed to the implementation of the main reaction. We take a 4-liter flask and add 400 gm of diphenylacetonitrile and the sodium hydroxide solution that we prepared above. After that, without fail, add 25 ml of tetrabutylammonium. We begin to cook all this slowly, stirring occasionally. Then, in this mixture, we gradually begin to add 800 ml of the previously prepared base. Within 2-3 hours, if everything was done correctly, the base will be completely used up.

For 8-12 hours, the cooking temperature should be kept in the region of 50-60 degrees Celsius. The result should be a thick mixture, light beige in color. Pour it into separate containers and freeze in the freezer. Further, the resulting mixture is crushed and washed with water. All this is best done in a gas mask and gloves, as certain parts of the mixture can be extremely toxic. We take a mortar, add petroleum ether there, put pieces of the obtained nitrile there and grind it. It is necessary to carefully grind each particle of the substance. It is necessary to replace the ether in the mortar with a new one about 4-5 times. The resulting beige crystals are dried in the open air.

Now the second stage of synthesis. We dissolve 300 grams of nitrile crystals in 300 ml of xylene. Then add 780 ml of ethylmagnesium bromide in ether to this solution. The solution is boiled at a temperature of 80°C for three hours. Then carefully add 15% hydrochloric acid to the solution. After the acid reaction is carried out, pour everything into glasses and send it to the freezer for 10 hours. The resulting crystals need to be recrystallized a couple more times from methanol, and that's it, the synthesis is completed. The resulting substance is enough for one dose of 250 mg.
 
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